Human Cancer Biology Analysis of MiR-195 and MiR-497 Expression, Regulation and Role in Breast Cancer
نویسندگان
چکیده
Purpose: To investigate expression, regulation, potential role and targets of miR-195 and miR-497 in
منابع مشابه
Analysis of MiR-195 and MiR-497 expression, regulation and role in breast cancer.
PURPOSE To investigate expression, regulation, potential role and targets of miR-195 and miR-497 in breast cancer. EXPERIMENTAL DESIGN The expression patterns of miR-195 and miR-497 were initially examined in breast cancer tissues and cell lines by Northern blotting and quantitative real-time PCR. Combined bisulfite restriction analysis and bisulfite sequencing were carried out to study the D...
متن کاملThe effect of a VEGFB antagonist peptide on the expression level of miR-210 in a mouse model of breast cancer
Breast cancer is the fourth common cancer worldwide and occurs when breast cells begin to uncontrolled division and tumor formation. Angiogenesis is one of the essential factors in cell growth and maintenance of homeostasis in the natural and pathological conditions, while VEGFs are the most critical factors in angiogenesis. MiR-210 plays an important role in the angiogenesis via association wi...
متن کاملCorrelation between Expression of hsa-miR-490-5p and NFAT5 in Peripheral Blood Mononuclear Cell Obtained from Breast Cancer Patients
Breast cancer is a complex genetic disease that has an average annual incidence of two million people and the second leading cause of death among women all over the world. Micro-RNAs are consistently reported to regulate gene expression in all cancers. The present study, the correlation between the expression of hsa-miR-490-5p and nuclear factor of activated T-cells 5 (NFAT5) in breast cancer w...
متن کاملMiR-6165 Dysregulation in Breast Cancer and Its Effect on Cell Proliferation and Migration
Background: ncRNAs have been identified as oncogenic drivers and tumor suppressors in any type of cancer. Although many classes of ncRNAs have been reported, most studies have been performed on microRNAs (miRNAs). miRNAs can regulate several target genes and affect important processes such as homeostasis, angiogenesis, cell proliferation, differentiation, and apoptosis. Located in the p75NTR ge...
متن کاملThe MicroRNA Expression Signature of Bladder Cancer by Deep Sequencing: The Functional Significance of the miR-195/497 Cluster
Current genome-wide microRNA (miRNA) expression signature analysis using deep sequencing technologies can drive the discovery of novel cancer pathways regulated by oncogenic and/or tumor suppressive miRNAs. We determined the genome-wide miRNA expression signature in bladder cancer (BC) by deep sequencing technology. A total of ten small RNA libraries were sequenced (five BCs and five samples of...
متن کامل